Keith M Channon Selected Research

sapropterin (tetrahydrobiopterin)

12/2018	Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin.
1/2018	Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.
1/2018	Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
3/2016	Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling.
6/2015	Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
9/2014	Effects of tetrahydrobiopterin oral treatment in hypoxia-induced pulmonary hypertension in rat.
2/2014	α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.
10/2013	Myocardial protection by co-administration of L-arginine and tetrahydrobiopterin during ischemia and reperfusion.
9/2013	Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.
11/2012	The role of tetrahydrobiopterin in inflammation and cardiovascular disease.

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Keith M Channon Research Topics

Disease

46	Atherosclerosis 12/2022 - 01/2003
32	Inflammation (Inflammations) 01/2022 - 01/2003
28	ST Elevation Myocardial Infarction 01/2022 - 05/2011
19	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 12/2009
19	Coronary Artery Disease (Coronary Atherosclerosis) 01/2020 - 04/2002
18	Vascular Diseases (Vascular Disease) 01/2017 - 09/2003
15	Infarction (Infarctions) 02/2022 - 10/2013
14	Atherosclerotic Plaque (Atheroma) 01/2021 - 11/2003
12	Myocardial Infarction 02/2022 - 05/2011
12	Heart Failure 01/2022 - 10/2003
10	Phenylketonurias (Phenylketonuria) 01/2017 - 07/2004
8	Atrial Fibrillation 01/2022 - 09/2005
7	Hyperplasia 11/2022 - 10/2002
7	Thrombosis (Thrombus) 01/2021 - 12/2007
6	Reperfusion Injury 01/2022 - 12/2010
5	Peritonitis 01/2022 - 10/2006
5	Aortic Aneurysm (Aneurysm, Aortic) 01/2021 - 03/2015
5	Ischemia 01/2021 - 07/2007
5	Myocardial Ischemia (Ischemic Heart Diseases) 01/2021 - 10/2013
5	Insulin Resistance 01/2020 - 02/2008
5	Diabetes Mellitus 01/2016 - 04/2002
4	Edema (Dropsy) 01/2022 - 05/2011
4	Fibrosis (Cirrhosis) 12/2021 - 05/2008
4	Obesity 12/2021 - 02/2008
4	Coronary Disease (Coronary Heart Disease) 10/2020 - 10/2004
4	Hypertension (High Blood Pressure) 01/2018 - 02/2007
4	Vascular Remodeling 01/2018 - 08/2006
4	Bradycardia 11/2017 - 02/2007
4	Vascular System Injuries 06/2015 - 04/2007
4	Hypoxia (Hypoxemia) 09/2014 - 04/2005
4	Hypertrophy 03/2013 - 05/2008
3	Disease Progression 11/2022 - 03/2007
3	COVID-19 01/2022 - 10/2020
3	Aneurysm (Aneurysms) 01/2021 - 04/2011
3	Infections 11/2020 - 12/2004
3	Rupture 01/2018 - 03/2015
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2018 - 12/2008
3	Type 2 Diabetes Mellitus (MODY) 06/2015 - 03/2007
3	Parkinson Disease (Parkinson's Disease) 05/2015 - 12/2008
3	Pulmonary Hypertension 09/2014 - 04/2005
3	Wounds and Injuries (Trauma) 05/2014 - 09/2002
3	Neointima 11/2013 - 11/2003
2	Cardiac Arrhythmias (Arrythmia) 01/2022 - 11/2020
2	Non-ST Elevated Myocardial Infarction 01/2022 - 01/2020
2	Neoplasms (Cancer) 01/2022 - 01/2018
2	Sepsis (Septicemia) 01/2022 - 11/2014
2	Acute Coronary Syndrome 01/2022 - 11/2019
2	Ventricular Tachycardia 10/2021 - 01/2020
2	Heart Arrest (Cardiac Arrest) 10/2021 - 01/2021
2	Hyperglycemia 01/2021 - 01/2016
2	Abdominal Aortic Aneurysm 01/2021 - 01/2018

Drug/Important Bio-Agent (IBA)

29	sapropterin (tetrahydrobiopterin)FDA Link 12/2018 - 03/2004
26	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 03/2004
20	Superoxides (Superoxide)IBA 12/2021 - 04/2002
19	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 09/2003
18	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 06/2013 - 04/2002
16	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 01/2017 - 03/2004
13	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2022 - 04/2002
13	Nitric Oxide Synthase (NO Synthase)IBA 03/2016 - 04/2002
12	Apolipoproteins E (ApoE)IBA 06/2022 - 03/2004
11	Proteins (Proteins, Gene)FDA Link 01/2018 - 10/2004
11	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2017 - 04/2008
10	EnzymesIBA 10/2020 - 03/2004
9	Biomarkers (Surrogate Marker)IBA 12/2022 - 09/2014
9	Angiotensin IIIBA 01/2021 - 02/2006
8	ChemokinesIBA 03/2015 - 01/2003
7	GadoliniumIBA 01/2022 - 05/2011
7	ApolipoproteinsIBA 12/2014 - 10/2004
6	TroponinIBA 01/2022 - 09/2015
6	AntioxidantsIBA 12/2021 - 07/2007
5	Biological ProductsIBA 11/2021 - 12/2015
5	CC ChemokinesIBA 12/2015 - 01/2003
5	BiopterinsIBA 03/2012 - 12/2007
4	Neuropeptide YIBA 01/2022 - 08/2013
4	C-Reactive ProteinIBA 01/2022 - 09/2009
4	Phosphotransferases (Kinase)IBA 01/2022 - 01/2013
4	ZymosanIBA 01/2022 - 08/2011
4	CalciumIBA 01/2022 - 11/2019
4	Adenosine (Adenocard)FDA LinkGeneric 06/2021 - 01/2017
4	LDL CholesterolIBA 01/2017 - 04/2008
3	VaccinesIBA 01/2022 - 10/2011
3	omega-Chloroacetophenone (Mace)IBA 01/2021 - 11/2011
3	Insulin (Novolin)FDA Link 01/2020 - 08/2011
3	LipidsIBA 11/2019 - 05/2010
3	AdiponectinIBA 06/2015 - 06/2013
3	Chemokine CX3CL1IBA 12/2014 - 11/2003
3	Protein Isoforms (Isoforms)IBA 06/2014 - 02/2006
3	erucylphosphocholineIBA 05/2014 - 12/2010
3	LigandsIBA 06/2012 - 10/2007
3	ferric oxide (iron oxide)IBA 06/2012 - 10/2007
3	NADP (NADPH)IBA 01/2012 - 01/2008
3	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 05/2010 - 10/2003
2	RNA (Ribonucleic Acid)IBA 01/2021 - 06/2015
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 10/2020 - 01/2009

Therapy/Procedure

26	Percutaneous Coronary Intervention 01/2022 - 07/2007
18	Stents 11/2022 - 10/2002
12	Therapeutics 01/2022 - 05/2007
10	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 11/2022 - 05/2007
3	Drug-Eluting Stents 06/2015 - 10/2004
2	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2021 - 01/2018